সংজ্ঞা

Stem cells produce red blood cells, white blood cells, and platelets. In some cases, stem cells in your bone marrow may not be functioning well or need to be destroyed to help treat a disease. If this happens, you will need new stem cells.

During this procedure, healthy stem cells are taken from a donor’s:

The stem cells will be injected into your vein. The new cells travel through the bloodstream to your bone cavities. It may take about a month for the donor stem cells in the bone marrow to begin to function fully. If the transplant is successful, new bone marrow cells will produce healthy red blood cells, white blood cells, and platelets.

Stem cell transplantation may be done using:

  • Stem cells that were taken from your own bone marrow or blood and stored
  • Stem cells from a donor

Hematopoietic Stem Cell Transplantation 2

পদ্ধতির কারণ

This procedure is done if the stem cells in your bone marrow are not functioning or are deficient. This may be caused by:

  • সংক্রমণ
  • Cancer (eg, leukemia, lymphoma)
  • Cancer treatment (eg, chemotherapy, radiation)
  • Immunodeficiency disorders
  • Severe anemia (eg, aplastic anemia)
  • Blood disorders (eg, sickle cell disease, thalassemia)

সম্ভাব্য জটিলতা

Complications are rare, but no procedure is completely free of risk. If you are planning to have a stem cell transplant, your doctor will review a list of possible complications, which may include:

  • Infection—until the donor blood-forming cells begin to function
  • Rejection of the donor stem cells
  • Acute graft versus host disease (when the immune cells in the donor’s bone marrow attack your tissue)

Possible complications for the donor include:

  • রক্তপাত
  • সংক্রমণ

Stem cell transplant is usually avoided if you have:

  • Disease of the heart, lungs, liver, or kidneys
  • ডায়াবেটিস

Be sure to discuss the risks with your doctor before the transplant.

কি আশা করা যায়

পদ্ধতির আগে

The donor will be carefully tested to check for diseases. Both you and the donor will be tested to ensure that your tissues are compatible. In order for the transplant to be successful, certain markers on the blood cells and bone marrow cells, called HLS types, must match.

As the recipient, you will be given medication to suppress your immune system. This is to prevent your body from rejecting the donor stem cells. In the weeks prior to the transplant, you may have to have:

  • কেমোথেরাপি
  • বিকিরণ থেরাপির

This process is called “conditioning.” It will rid the body of diseased cells and clear the bone marrow cavities for the new bone marrow.

এনেস্থেশিয়া

  • Donor—general anesthesia to block pain and keep the donor asleep through the procedure; given through an IV in the hand or arm
  • Recipient—will not need any anesthesia

পদ্ধতির বর্ণনা

If the stem cells will be from the donor’s bone marrow (BMT), the doctor will clean an area of the donor’s hip. A hollow needle and syringe will be used to remove the bone marrow. The doctor will make several small punctures. This is to harvest enough bone marrow for the transplant (1-2 quarts). Lastly, the wounds will be covered with bandages.

If the stem cells will be from the donor’s blood (PBSC), the doctor will stick a needle in the donor’s large vein or veins in the arms. A machine will receive blood from the vein. This machine will spin the blood so that the stem cells are concentrated. The rest of the blood will be given back to the donor. The doctor will cover the puncture wounds with bandages. This procedure may require more than one blood donation. The donor may also be required to take pills that cause more stem cells from the bone marrow to go into the blood.

The donated stem cells will be filtered. Next, the doctor will administer the cells through a small, flexible tube, called a catheter, into one of your large veins.

অবিলম্বে প্রক্রিয়া পরে

The donor will recover quickly. You, the recipient, will need to be placed in isolation. This is to avoid infection until the new stem cells in the bone marrow begin to produce infection-fighting cells.

কতক্ষণ এটা লাগবে?

  • Donor
    • BMT—about 30 minutes
    • PBSC—several hours
  • Recipient—several hours

এটা কতটা আঘাত করবে?

  • Donor:
    • If the procedure done is a BMT, then the donor will have general anesthesia during the transplant. There may be pain and discomfort after the anesthesia wears off.
    • If the procedure done is a PBSC transplant, then the donor will have pain from the needle sticks.
  • Recipient—There will not be pain while the stem cells are infused. You may have some nausea. This can be treated with medication.

গড় হাসপাতালে থাকার

  • Donor
    • For BMT—overnight
    • For PBSC—several donations (each donation lasts a couple of hours)
  • Recipient—1-2 months

পোস্ট-প্রক্রিয়া যত্ন

The donor may receive:

  • ব্যথার ওষুধ
  • সংক্রমণ প্রতিরোধ করতে অ্যান্টিবায়োটিক

আপনি হাসপাতালে পুনরুদ্ধার করার সময়, আপনি নিম্নলিখিত যত্ন পেতে পারেন:

  • Medication that keep your immune system low to decrease the chance of transplant rejection
  • সংক্রমণ প্রতিরোধ করতে অ্যান্টিবায়োটিক
  • Platelets, plasma, and red blood cell transfusions to prevent bleeding and anemia
  • Frequent blood tests to monitor whether the new stem cells in the bone marrow are taking hold or being rejected

আপনার ডাক্তারকে কল করুন

আপনি হাসপাতাল ছেড়ে যাওয়ার পরে, নিম্নলিখিতগুলির মধ্যে যেকোনটি ঘটলে আপনার ডাক্তারের সাথে যোগাযোগ করুন:

  • বমি বমি ভাব এবং/অথবা বমি
  • তীব্র ব্যথা
  • New onset of pain (more than 24 hours after the transplant)
  • Redness, swelling, increasing pain, excessive bleeding, or discharge from the catheter site
  • Signs of infection; including fever and chills
  • ফুসকুড়ি
  • ডায়রিয়া

জরুরী পরিস্থিতিতে, অবিলম্বে চিকিৎসা সহায়তার জন্য কল করুন।

 

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