সংজ্ঞা
Chronic granulomatous disease develops when a specific gene from both parents passes to the child. This gene causes abnormal cells to develop in the immune system. The abnormal cells are called phagocytic cells. They normally kill bacteria. With this disease, these cells cannot work properly. As a result, the body can not fight some types of bacteria. It also makes infections likely to return.
The increased risk of infections can lead to premature death. Repeated lung infections are often the cause of death with this disease. Preventative care and treatment can help to reduce and temporarily control infections.
CGD is a rare condition.
কারণসমূহ
The disease is usually caused by a recessive gene. This means two of these defective genes have to be present for the disease to develop. This gene is carried on the X chromosome. Both parents must have the gene.
ঝুঁকির কারণ
The following factors increase your chance of developing CGD:
- Parents who have the recessive trait
- নারী হওয়া
লক্ষণ
Typically, symptoms begin to appear in childhood. In some, they may not appear until the teen years.
উপসর্গ অন্তর্ভুক্ত:
- Swollen lymph nodes in the neck
- Frequent skin infections that are resistant to treatment, such as:
- Abscesses
- Boils
- Persistent diarrhea
- হাড়ের ব্যথা
- সংযোগে ব্যথা
রোগ নির্ণয়
আপনার ডাক্তার আপনার লক্ষণ এবং চিকিৎসা ইতিহাস সম্পর্কে জিজ্ঞাসা করবে। একটি শারীরিক পরীক্ষা সম্পন্ন করা হবে।
পরীক্ষায় নিম্নলিখিতগুলি অন্তর্ভুক্ত থাকতে পারে:
- You may have you bodily fluids and tissue tested. This can be done with:
- বায়োপসি
- সম্পূর্ণ রক্ত গণনা (CBC)
- Dihydrorhodamine reduction (DHR) flow cytometry test—a blood test that looks at the ability of phagocytes to make chemicals that can destroy bacteria
- Erythrocyte sedimentation rate (ESR)—to test for inflammation
- You may have pictures taken of your bodily structures. This can be done with:
- বুকের এক্স - রে
- হাড় স্ক্যান
- Liver scan
চিকিৎসা
আপনার জন্য সেরা পরিকল্পনা সম্পর্কে আপনার ডাক্তারের সাথে কথা বলুন। চিকিত্সার বিকল্পগুলির মধ্যে রয়েছে:
ওষুধ
You may be given medications to treat this condition.
- Antibiotics—used to prevent and treat infections
- Interferon gamma —reduces the number of infections in patients; not useful in newly active infections
বোন ম্যারো ট্রান্সপ্লান্টেশন
Bone marrow transplantation may be an option. A suitable donor will need to be found. It is a definitive cure.
সার্জারি
Surgery may involve the removal of abscesses.
টিকা
Some live viral vaccines should be avoided. You should talk to your doctor before receiving one.
প্রতিরোধ
CGD is an inherited disease. There are no preventive steps to reduce the risk of being born with the disease. Genetic counseling may be helpful. It can be used to detect carrier status in woman. Early diagnosis is vital. It will allow for early treatment. The bone marrow transplant donor search can also be started.