تعريف

Cardiomyopathy is a heart disease. The damaged heart does not pump blood correctly. The disease usually progresses, and patients develop life-threatening heart failure. People with cardiomyopathy are also more likely to have irregular heartbeats or arrhythmias.

There are two categories of cardiomyopathy: ischemic and non-ischemic. Ischemic cardiomyopathy is most common. It occurs when the heart is damaged from heart attacks due to coronary artery disease. Non-ischemic cardiomyopathy is less common. It includes types of cardiomyopathy that are not related to coronary artery disease.

There are three main types of non-ischemic cardiomyopathy:

  • Dilated—Damaged heart muscles lead to an enlarged, floppy heart. The heart stretches as it tries to make up for a weakened ability to pump.
  • Hypertrophic—Heart muscle fibers enlarge abnormally. The heart does not relax correctly between beats. The heart wall thickens, leaving less space for blood to fill the chambers, so less blood is pumped from the heart.
  • Restrictive—Parts of the heart wall stiffen. Thickening often occurs due to abnormal tissue invading the heart.

اعتلال عضلة القلب

أسباب

In many cases, the exact cause is not known. Possible causes include:

Dilated

The cause of the initial damage is often not found, but may include:

  • Ischemic heart disease with decreased blood flow to your heart
  • Infections, usually viral
  • Chronic exposure to toxins, including alcohol and some chemotherapy drugs
  • A rare complication of pregnancy or childbirth (probably immune-related)
  • Rarely, other illnesses, including rheumatoid arthritis, diabetes, or thyroid disease

Hypertrophic

Causes may include:

  • Inherited (sometimes present at birth but often developing in teens)
  • Aging, associated with hypertension

Restrictive

Causes are usually related to another condition, such as:

  • Amyloidosis—Protein fibers collect in the heart
  • Sarcoidosis—Small inflammatory masses (granulomas) form in many organs
  • Hemochromatosis—Too much iron in the body

عوامل الخطر

Factors that increase your chance of getting cardiomyopathy include:

  • Family members with cardiomyopathy
  • إدمان الكحول
  • السمنة
  • مرض السكري
  • ارتفاع ضغط الدم
  • مرض القلب التاجي
  • Certain drugs

الأعراض

Symptoms vary, depending on the type of cardiomyopathy and its severity.

Cardiomyopathy leads to heart failure and the following symptoms:

  • تعب
  • ضعف
  • Shortness of breath, often worse when lying down or with activity
  • سعال
  • Swelling in feet or legs
  • ألم في الصدر
  • Irregular heart rhythm

التشخيص

Your doctor will ask about your symptoms and medical history. A physical exam will be done. A stethoscope will be used to listen to your heart. Cardiomyopathies often produce heart murmurs and other abnormal sounds.

  • Your doctor may need pictures of your chest. This can be done with:
    • الأشعة السينية الصدر
    • مخطط صدى القلب
  • Tests may be done to determine how your heart functions. These can be done with:
    • تخطيط القلب الكهربي
    • قسطرة القلب
  • Your bodily fluids and tissue may need to be tested. This can be done with:
    • تحاليل الدم
    • Heart biopsy

العلاج

Heart failure may be due to blockages in the arteries. Treatments to relieve these blockages include angioplasty, stent placement, and coronary artery bypass surgery. These may lead to improved heart function and symptoms. For certain genetic causes, other treatments may also improve heart function. For many patients, however, treatment is aimed at relieving symptoms and preventing further damage.

Lifestyle Modification

Changes to eliminate anything that adds to the disease or worsens symptoms:

  • تجنب الكحول.
  • If you are overweight, lose weight.
  • Eat a low-fat diet to reduce the risk and extent of coronary artery disease.
  • Limit salt intake to reduce fluid retention.
  • Follow your doctor’s advice about exercise. You may need to limit physical activity.

الأدوية

قد تشمل الأدوية ما يلي:

  • Diuretics—To remove extra fluid
  • Angiotensin-converting enzyme (ACE) inhibitors—To relax blood vessels, lower blood pressure, and decrease the heart’s workload
  • Angiotensin receptor blockers—Similar to ACE inhibitors
  • Hydralazine and isosorbide dinitrate—May be used with ACE inhibitors
  • Digitalis—To slow and regulate heart rate, and slightly increase its force of contractions
  • Beta-blockers—To slow the heart and limit disease progression
  • Spironolactone—To improve outcome in people with dilated cardiomyopathy and advanced symptoms

جراحة

تشمل الخيارات الجراحية ما يلي:

  • A pacemaker may be implanted to improve heart rate and pattern.
  • For people with hypertrophic disease, doctors may remove part of the thickened wall that separates the heart’s chambers. Surgery may be needed to replace a heart valve. Another option is alcohol septal ablation. This procedure reduces symptoms and improves how the heart functions.
  • For those with life-threatening, irregular heart rhythms, a cardioverter defibrillatormay need to be implanted.
  • A heart transplant may be possible for otherwise healthy patients who do not respond to medical treatment. Candidates often wait a long time for a new heart. Those waiting may temporarily receive a ventricular assist device. This is a mechanical pump that takes over some of or most of the heart’s pumping function.

الوقاية

Actively treat hypertension, coronary artery diseases, and their risk factors. This is the best way to prevent most cases of cardiomyopathy. However, other less common causes are not preventable. If you have a family history of the disease, ask your doctor about screening tests. Do this especially before starting an intense exercise program.

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